Defending champions St Helens take on Super League leaders Leeds Rhinos. The teams have formed an epic rivalry in the modern era and have again been setting the pace at the top of the table in the first 10 weeks of the season. Wigan are at home to Warrington in a repeat of last year's play-off semi-final which the Warriors won in dramatic circumstances. Huddersfield play Catalans and Widnes are at home to Castleford. In the fifth round of the Challenge Cup, four Super League sides face championship opposition, including Salford Red Devils who are away to Leigh Centurions.